- Oct 16, 2026
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The 49ers have established themselves as the most dominant division favorite in the NFL, holding a perfect 6-0 record and a commanding three-game lead over the Seahawks in the NFC West.
San Francisco carries -650 odds to win the division, the steepest price of any team league-wide. The 49ers have already defeated all three division rivals head-to-head and hold a four-game advantage over both the Rams and Cardinals.
The Seahawks sit second in the division at 3-3 with +630 odds. The Rams and Cardinals are tied at 2-4, with the Cardinals listed as the longest division long shots in the NFL at +15,000. The Rams hold +1200 odds.
No other division leader approaches San Francisco's margin. The Jaguars rank as the next-biggest favorites at -290 in the AFC South, followed by the Chiefs at -250 in the AFC West. The Bills sit at -200 in the AFC East, while the Panthers lead the tightest race at -120 in the NFC South. The Ravens and Vikings are nearly even at -110 and +105 in the AFC North, and the Cowboys lead the NFC East at +130.
Source: ProFootballTalk - Wed Oct 21, 4:48 AM ET
Written by the SportsMafia Wire desk in our own words from the original reporting (AI-assisted, checked against the source).